Pathology

The assessment of genetic changes in tissue biopsies can provide important information for prediction of tumour progression. The majority of such changes are either chromosome amplifications or deletions but there are often other complex rearrangements that can be detected using FISH. Current methodologies, namely immunohistochemistry or Southern blotting, can provide information at the gene expression level but, when carried out on tissue sections, FISH can provide information at a gene level, in situ, at the precise site within the tumour. Tico Europe offers a comprehensive range of Cytocell solid tumour probes specific for a number of pathological malignancies, four of which are exclusive to Cytocell. The FISH probes are designed for use on solid tissue sections which are available in a 10 test kit.